In February 2012, Frontier Airlines cut five nonstop routes from Milwaukee. This move "reduced Frontier's daily departing flights out of Mitchell International from 32 to 18," or 56%. Frontier announced further layoffs in conjunction with this route change: up to 446 Milwaukee-area employees were affected by the job cuts that occurred between April 15 and April 30, 2012.
In February 2002, the airline launched its first regional product, Frontier JetExpress, initially operated by Mesa Airlines using CRJ-200 regional jets. Similar to "express" operations of other carriers, Frontier JetExpress was targeted for markets to and from Denver that do not generate traffic sufficient to support Frontier's smallest mainline jet, the Airbus A318, but could still offer lucrative business with a smaller jet.
After making a codeshare agreement with Lufthansa that went into effect in 2010, jetBlue transitioned to the Sabre reservation system used by Lufthansa, enabling the airlines to sell tickets on each other's flights, transfer luggage and passengers between the two carriers, and combine frequent flyer programs,. By making use of JetBlue's North America routes as a feeder network, the agreement put Lufthansa in a position to operate quasi-hubs in New York–JFK and Boston Logan.
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Following the February 2007 incident in which the airline was forced to cancel nearly 1,700 flights due to winter storms, jetBlue's board of directors replaced founder and Chief Executive Officer David Neeleman with Dave Barger. He had politicked the board, while Neeleman was busy publicly apologizing. Barger's ascendancy caused widespread demoralization in the ranks. He became JetBlue's new Chief Executive Officer on May 10, 2007. Neeleman, the company's founder and largest individual investor, became a nonexecutive chairman as a result of the change.
Chautauqua Airlines operated up to 12 Embraer 135 and 145 jets out of Milwaukee. Frontier began branding these flights as Frontier Express in the spring of 2011. With the pull-down of the Milwaukee hub, the only route that continued to operate with a Frontier Express ERJ-145 jet was Milwaukee to Rhinelander. However, Frontier service to Rhinelander ended on January 3, 2013, and Chautauqua transferred the remaining aircraft to other partners.
In October 2013, jetBlue introduced Mint, a premium cabin service on transcontinental and select Caribbean flights. The service began in 2014, using the Airbus A321-231 aircraft ordered by jetBlue. These planes are outfitted with winglets, as well as with "lie flat" seats, and moveable partitions that can create small suites on the airplane. Called "Mint" by jetBlue, these planes are configured with 16 business-class seats and 143 economy seats, instead of an all-economy configuration of 190 seats.
In an effort to focus on regional contract flights for major carriers, Republic Airways Holdings announced in January 2012 its intention to sell or spin off Frontier. On January 26, 2012, Republic Airways Holdings appointed former US Airways and Gate Gourmet CEO David Siegel as President and CEO of Frontier Airlines. Republic also added new senior officers for Frontier's finance and commercial team, among other changes in the executive leadership team. Siegel and other Frontier executives moved to Denver where Frontier is headquartered in order to facilitate management of all aspects of Frontier during its separation process from Republic and continue its transformation into an ultra-low-cost carrier.
JetBlue Technology Ventures (JTV)  is a wholly owned subsidiary of JetBlue that was established in February 2016. JTV is the venture capital arm of JetBlue that invests in and partners with early-stage startups in the travel, hospitality, and transportation space. Its mission is to improve the end-to-end experience of travelers everywhere. As of November 2018, JTV has invested in 21 startups, including hybrid planes, machine learning algorithms, and ground transportation. Investments range in size from $250,000 to $1 million.